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Phospho-Caspase 6(S257) Antibody

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Phospho-Caspase 6(S257) Antibody AP3043a
    Western blot analysis of anti-Phospho-Caspase-pS257 (Cat. #AP3043a) in liver cell line lysates (35ug/lane). Casp6-pS257(arrow) was detected using the purified Pab.
  • IHC-P - Phospho-Caspase 6(S257) Antibody AP3043a
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P55212
Other Accession O35397, O08738, Q3T0P5
Reactivity Human
Predicted Bovine, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 33310 Da
Additional Information
Gene ID 839
Other Names Caspase-6, CASP-6, Apoptotic protease Mch-2, Caspase-6 subunit p18, Caspase-6 subunit p11, CASP6, MCH2
Target/Specificity This Caspase 6 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S257 of human Caspase 6.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPhospho-Caspase 6(S257) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CASP6
Synonyms MCH2
Function Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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Caspase 6 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein could be processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade.


Kalinin, A.E., et al., J. Invest. Dermatol. 124(1):46-55 (2005).
Suzuki, A., et al., Oncogene 23(42):7067-7075 (2004).
Horowitz, P.M., et al., J. Neurosci. 24(36):7895-7902 (2004).
Schmeck, B., et al., Infect. Immun. 72(9):4940-4947 (2004).
Mendez, E., et al., J. Virol. 78(16):8601-8608 (2004).

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$ 295.00
$ 99.00
Cat# AP3043a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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