|Application ||WB, IHC-P, E|
|Other Accession||O35397, O08738, Q3T0P5|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||33310 Da|
|Other Names||Caspase-6, CASP-6, Apoptotic protease Mch-2, Caspase-6 subunit p18, Caspase-6 subunit p11, CASP6, MCH2|
|Target/Specificity||This Caspase 6 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S257 of human Caspase 6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Phospho-Caspase 6(S257) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.|
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Provided below are standard protocols that you may find useful for product applications.
Caspase 6 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein could be processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade.
Kalinin, A.E., et al., J. Invest. Dermatol. 124(1):46-55 (2005).
Suzuki, A., et al., Oncogene 23(42):7067-7075 (2004).
Horowitz, P.M., et al., J. Neurosci. 24(36):7895-7902 (2004).
Schmeck, B., et al., Infect. Immun. 72(9):4940-4947 (2004).
Mendez, E., et al., J. Virol. 78(16):8601-8608 (2004).
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