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Phospho-LPR1(S4520) Antibody

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • DB - Phospho-LPR1(S4520) Antibody AP3143a
    Dot blot analysis of anti-Phospho-LPR1-S4520 Antibody (Cat.#AP3143a) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.
  • IHC-P - Phospho-LPR1(S4520) Antibody AP3143a
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q07954
Other Accession Q91ZX7
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 504606 Da
Additional Information
Gene ID 4035
Other Names Prolow-density lipoprotein receptor-related protein 1, LRP-1, Alpha-2-macroglobulin receptor, A2MR, Apolipoprotein E receptor, APOER, CD91, Low-density lipoprotein receptor-related protein 1 85 kDa subunit, LRP-85, Low-density lipoprotein receptor-related protein 1 515 kDa subunit, LRP-515, Low-density lipoprotein receptor-related protein 1 intracellular domain, LRPICD, LRP1, A2MR, APR
Target/Specificity This LPR1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S4520 of human LPR1.
Dilution DB~~1:500
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPhospho-LPR1(S4520) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LRP1
Synonyms A2MR, APR
Function Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.
Cellular Location Low-density lipoprotein receptor-related protein 1 85 kDa subunit: Cell membrane; Single-pass type I membrane protein. Membrane, coated pit Low-density lipoprotein receptor-related protein 1 intracellular domain: Cytoplasm. Nucleus. Note=After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus
Tissue Location Most abundant in liver, brain and lung.
Research Areas
Citations (0)

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LPR1 is involved in the plasma clearance of chylomicron remnants and activated alpha 2-macroglobulin, as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors.


Yu, G., et al., Blood 105(9):3545-3551 (2005).
Cam, J.A., et al., J. Biol. Chem. 280(15):15464-15470 (2005).
Niemeier, A., et al., J. Bone Miner. Res. 20(2):283-293 (2005).
Spijkers, P.P., et al., Blood 105(1):170-177 (2005).
Deane, R., et al., Neuron 43(3):333-344 (2004).

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$ 295.00
$ 99.00
Cat# AP3143a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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