|Application ||DB, E|
|Other Accession||Q9QYY0, A6QLU3|
|Calculated MW||76616 Da|
|Other Names||GRB2-associated-binding protein 1, GRB2-associated binder 1, Growth factor receptor bound protein 2-associated protein 1, GAB1|
|Target/Specificity||This Gab1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y659 of human Gab1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Phospho-Gab1(Y659) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR).|
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Provided below are standard protocols that you may find useful for product applications.
Gab1 is a member of the IRS1-like multisubstrate docking protein family. This protein is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis.
Podar, K., et al., J. Biol. Chem. 279(20):21658-21665 (2004).
Ren, Y., et al., J. Biol. Chem. 279(9):8497-8505 (2004).
Kapoor, G.S., et al., Mol. Cell. Biol. 24(2):823-836 (2004).
Nakaoka, Y., et al., Circ. Res. 93(3):221-229 (2003).
Holgado-Madruga, M., et al., Mol. Cell. Biol. 23(13):4471-4484 (2003).
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