|Application ||DB, E|
|Other Accession||P22829, P12813|
|Calculated MW||64463 Da|
|Other Names||Nuclear receptor subfamily 4 group A member 1, Early response protein NAK1, Nuclear hormone receptor NUR/77, Nur77, Orphan nuclear receptor HMR, Orphan nuclear receptor TR3, ST-59, Testicular receptor 3, NR4A1, GFRP1, HMR, NAK1|
|Target/Specificity||This NR4A1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S351 of human NR4A1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Phospho-NR4A1(S351) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GFRP1, HMR, NAK1|
|Function||Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'- AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation.|
|Cellular Location||Cytoplasm. Nucleus.|
|Tissue Location||Fetal muscle and adult liver, brain and thyroid|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
NR4A1 is a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis.
Lu, L., et al., J. Clin. Endocrinol. Metab. 89(8):4113-4118 (2004).
Castro-Obregon, S., et al., J. Biol. Chem. 279(17):17543-17553 (2004).
Lin, B., et al., Cell 116(4):527-540 (2004).
Choi, J.W., et al., Cancer Res. 64(1):35-39 (2004).
Ye, X., et al., Int. J. Biochem. Cell Biol. 36(1):98-113 (2004).
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