|Application ||DB, E|
|Other Accession||P22829, P12813|
|Calculated MW||64463 Da|
|Other Names||Nuclear receptor subfamily 4 group A member 1, Early response protein NAK1, Nuclear hormone receptor NUR/77, Nur77, Orphan nuclear receptor HMR, Orphan nuclear receptor TR3, ST-59, Testicular receptor 3, NR4A1, GFRP1, HMR, NAK1|
|Target/Specificity||This NR4A1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S351 of human NR4A1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Phospho-NR4A1(S351) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GFRP1, HMR, NAK1|
|Function||Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'- AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation.|
|Cellular Location||Cytoplasm. Nucleus.|
|Tissue Location||Fetal muscle and adult liver, brain and thyroid|
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
NR4A1 is a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis.
Lu, L., et al., J. Clin. Endocrinol. Metab. 89(8):4113-4118 (2004).
Castro-Obregon, S., et al., J. Biol. Chem. 279(17):17543-17553 (2004).
Lin, B., et al., Cell 116(4):527-540 (2004).
Choi, J.W., et al., Cancer Res. 64(1):35-39 (2004).
Ye, X., et al., Int. J. Biochem. Cell Biol. 36(1):98-113 (2004).
If you have any additional inquiries please email technical services at email@example.com.