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Phospho-MAPT-S720 AntibodyPeptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP3381a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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Phospho-MAPT-S720 Antibody - Product info | |
| Application | DB
|
| Primary Accession | P10636 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 78928 Da |
Phospho-MAPT-S720 Antibody - Additional info | |
| Gene ID 4137 | |
| Other Names MAPT; MAPTL; MTBT1; TAU; Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau | |
| Target/Specificity This Phospho-MAPT-S720 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S720 of human MAPT. | |
| Dilution DB~~1:100~500 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is first purified by protein A affinity chromatography. Then, the antibody fraction is peptide affinity purified in a 2-step procedure with peptides. The antibody is eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Phospho-MAPT-S720 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
Phospho-MAPT-S720 Antibody - Protein Information | |
| Name MAPT | |
| Synonyms MAPTL, MTBT1, TAU | |
| Function Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization | |
| Cellular Location Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components | |
| Tissue Location Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system | |
Phospho-MAPT-S720 Antibody - Related products
AP1425c: TAU (MAPT) Antibody (S720)
AP2040b: TAU Antibody (C-term)
AP3381a: Phospho-MAPT-S720 Antibody
DC09953: Human MAPT cDNA Clone
LY12097a: MAPT Over-expression Lysate
BP1425c: MAPT Antibody (S720) Blocking Peptide
BP2040b: TAU Antibody (C-term) Blocking Peptide
BP3381a: Phospho-MAPT-S720 Antibody Blocking Peptide
AJ1757a: Tau Antibody Phospho (pS198)
AJ1757b: Tau Antibody Phospho (pS202)
AJ1757c: Tau Antibody Phospho (pS262)
AJ1757d: Tau Antibody Phospho (pS356)
AJ1757e: Tau Antibody Phospho (pS404)
Phospho-MAPT-S720 Antibody - Application data
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Dot blot analysis of Phospho-MAPT-S720 Antibody (Cat. #AP3381a) and MAPT Non Phospho-specific Pab on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.
Phospho-MAPT-S720 Antibody - Research Areas
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BACKGROUND
MAPT promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
REFERENCES
Chun,W., J. Biol. Chem. 282 (32), 23410-23417 (2007) Hanger,D.P., J. Biol. Chem. 282 (32), 23645-23654 (2007)
