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Phospho-EIF4EBP1-pT36 AntibodyPeptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP3417a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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Phospho-EIF4EBP1-pT36 Antibody - Product info | |
| Application | DB
|
| Primary Accession | Q13541 |
| Other Accession | NP_004086 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 12580 Da |
Phospho-EIF4EBP1-pT36 Antibody - Additional info | |
| Gene ID 1978 | |
| Other Names EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1 | |
| Target/Specificity This Phospho-EIF4EBP1-pT36 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T36 of human EIF4EBP1. | |
| Dilution DB~~1:500 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is first purified by protein A affinity chromatography. Then, the antibody fraction is peptide affinity purified in a 2-step procedure with peptides. The antibody is eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Phospho-EIF4EBP1-pT36 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
Phospho-EIF4EBP1-pT36 Antibody - Protein Information | |
| Name EIF4EBP1 | |
| Function Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways | |
Phospho-EIF4EBP1-pT36 Antibody - Related products
AM1938a: EIF4EBP1 Antibody (ascites)
AP12627c: EIF4EBP1 Antibody (Center)
AP1981a: EIF4EBP1 Antibody (S100)
AP1981b: EIF4EBP1 Antibody (T36)
AP1981c: EIF4EBP1 Antibody (T69)
AP1981d: EIF4EBP1 Antibody(S111)
AP3353a: Phospho-EIF4EBP1-pS100 Antibody
AP3417a: Phospho-EIF4EBP1-pT36 Antibody
AP3473a: Phospho-EIF4EBP1-S111 Antibody
RI11733: EIF4EBP1 predesign siRNA
DC01492: Human EIF4EBP1 cDNA Clone
LY10995a: EIF4EBP1 Over-expression Lysate
BP1981a: EIF4EBP1 Antibody (S100) Blocking Peptide
BP1981b: EIF4EBP1 Antibody (T36) Blocking Peptide
BP1981c: EIF4EBP1 Antibody (T69) Blocking Peptide
BP3417a: Phospho-EIF4EBP1-pT36 Antibody Blocking Peptide
BP3473a: Phospho-EIF4EBP1-S111 Antibody Blocking Peptide
AJ1004d: 4E-BP1 Antibody Phospho (pT37)
AJ1004e: 4E-BP1 Antibody Phospho (pT70)
AJ1004f: 4E-BP1/2/3 Antibody Phospho (pT45)
Phospho-EIF4EBP1-pT36 Antibody - Application data
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Dot blot analysis of anti-EIF4EBP1-pT36 Phospho-specific Pab (Cat.#AP3416a) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.
Phospho-EIF4EBP1-pT36 Antibody - Research Areas
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
EIF4EBP1 is a member of a family of translation repressor proteins. This protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. It is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
REFERENCES
Fonseca,B.D., J. Biol. Chem. 282 (34), 24514-24524 (2007) Armengol,G., Cancer Res. 67 (16), 7551-7555 (2007)
