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Phospho-FLNA-pY1046 AntibodyPeptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP3528a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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- Backgrounds
Phospho-FLNA-pY1046 Antibody - Product info | |
| Application | DB
|
| Primary Accession | P21333 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 280739 Da |
Phospho-FLNA-pY1046 Antibody - Additional info | |
| Gene ID 2316 | |
| Other Names FLNA; FLN; FLN1; Filamin-A; Actin-binding protein 280; Alpha-filamin; Endothelial actin-binding protein; Filamin-1; Non-muscle filamin | |
| Target/Specificity This Phospho-FLNA-pY1046 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1046 of human FLNA. | |
| Dilution DB~~1ÂF500 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by two-step phosphospecific peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Phospho-FLNA-pY1046 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
Phospho-FLNA-pY1046 Antibody - Protein Information | |
| Name FLNA | |
| Synonyms FLN, FLN1 | |
| Function Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface- localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis | |
| Cellular Location Cytoplasm, cell cortex. Cytoplasm, cytoskeleton | |
| Tissue Location Ubiquitous. | |
Phospho-FLNA-pY1046 Antibody - Related products
AP3379a: Phospho-FLNA-S2152 Antibody
AP3401a: Phospho-FLNA-S2522 Antibody
AP3528a: Phospho-FLNA-pY1046 Antibody
AP7770a: FLNA Antibody (Y1046)
BP3379a: Phospho-FLNA-S2151 Antibody Blocking Peptide
BP3401a: Phospho-FLNA-S2522 Antibody Blocking Peptide
BP3528a: Phospho-FLNA-pY1046 Antibody Blocking Peptide
AJ1299a: Filamin-A Antibody (C-term)
Phospho-FLNA-pY1046 Antibody - Application data
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Dot blot analysis of anti-FLNA Phospho-specific Pab (Cat.#AP3528a) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.
Phospho-FLNA-pY1046 Antibody - Research Areas
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BACKGROUND
Actin-binding protein, or filamin, is a 280-kD protein that crosslinks actin filaments into orthogonal networks in cortical cytoplasm and participates in the anchoring of membrane proteins for the actin cytoskeleton. Remodeling of the cytoskeleton is central to the modulation of cell shape and migration. Filamin A, encoded by the FLNA gene, is a widely expressed protein that regulates reorganization of the actin cytoskeleton by interacting with integrins, transmembrane receptor complexes, and second messengers.
REFERENCES
Wang,Y., Oncogene 26 (41), 6061-6070 (2007) Lad,Y., EMBO J. 26 (17), 3993-4004 (2007) Cho,E.Y., Mol. Endocrinol. 21 (9), 2242-2254 (2007)
