|Application ||DB, E|
|Calculated MW||60033 Da|
|Other Names||Transcription factor GATA-6, GATA-binding factor 6, GATA6|
|Target/Specificity||This GATA6 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y271 of human GATA6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Phospho-GATA6(Y271) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional activator that regulates SEMA3C and PLXNA2 (PubMed:19666519). Involved in gene regulation specifically in the gastric epithelium (PubMed:9315713). May regulate genes that protect epithelial cells from bacterial infection (PubMed:16968778). Involved in bone morphogenetic protein (BMP)- mediated cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity).|
|Tissue Location||Expressed in heart, gut and gut-derived tissues|
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Provided below are standard protocols that you may find useful for product applications.
GATA6 may be important for regulating terminal differentiation and/or proliferation.
Kwei,K.A., PLoS Genet. 4 (5), E1000081 (2008)
Ghatnekar,A., Biochim. Biophys. Acta 1779 (3), 145-151 (2008)
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