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Phospho-ZBTB16(Y334) Antibody

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • DB - Phospho-ZBTB16(Y334) Antibody AP3575a
    Dot blot analysis of anti-Phospho-ZBTB16-pY334 Antibody (Cat.#AP3575a) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
DB, E
Primary Accession Q05516
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 74274 Da
Additional Information
Gene ID 7704
Other Names Zinc finger and BTB domain-containing protein 16, Promyelocytic leukemia zinc finger protein, Zinc finger protein 145, Zinc finger protein PLZF, ZBTB16, PLZF, ZNF145
Target/Specificity This ZBTB16 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y334 of human ZBTB16.
Dilution DB~~1:500
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPhospho-ZBTB16(Y334) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZBTB16
Synonyms PLZF, ZNF145
Function Acts as a transcriptional repressor (PubMed:10688654, PubMed:24359566). Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters (PubMed:10688654). May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312).
Cellular Location Nucleus. Nucleus, nuclear body
Tissue Location Within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines and peripheral blood mononuclear cells. Also expressed in the ovary, and at lower levels, in the kidney and lung
Research Areas
Citations (0)
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Background

ZBTB16 is a member of the Krueppel C2H2-type zinc-finger protein family. It is a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase.

References

Labbaye,C., Nat. Cell Biol. 10 (7), 788-801 (2008)
Kang,S.I., Biochem. Biophys. Res. Commun. 369 (4), 1209-1214 (2008)
Felicetti,F., Cancer Res. 68 (8), 2745-2754 (2008)

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$ 365.00
$ 140.00
Cat# AP3575a
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