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Phospho-DCX-pS128 AntibodyPeptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP3582a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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- Backgrounds
Phospho-DCX-pS128 Antibody - Product info | |
| Application | DB
|
| Primary Accession | O43602 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 49318 Da |
Phospho-DCX-pS128 Antibody - Additional info | |
| Gene ID 1641 | |
| Other Names DCX; DBCN; LISX; Neuronal migration protein doublecortin; Doublin; Lissencephalin-X | |
| Target/Specificity This Phospho-DCX-pS128 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between 115~144 amino acids surrounding S128 of human DCX. | |
| Dilution DB~~1:500 | |
| Format This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S128 of human DCX. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Phospho-DCX-pS128 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
Phospho-DCX-pS128 Antibody - Protein Information | |
| Name DCX | |
| Synonyms DBCN, LISX | |
| Function Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration | |
| Cellular Location Cytoplasm. Cell projection (By similarity). Note=Localizes at neurite tips (By similarity) | |
| Tissue Location Highly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the adult, highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas | |
Phospho-DCX-pS128 Antibody - Related products
AP3551a: Phospho-DCX-pS378 Antibody
AP3582a: Phospho-DCX-pS128 Antibody
LY11440a: DCX Over-expression Lysate
BP2768a: DCX Antibody (S128) Blocking Peptide
BP3551a: Phospho-DCX-pS378 Antibody Blocking Peptide
Phospho-DCX-pS128 Antibody - Application data
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Dot blot analysis of anti-Phospho-DCX-pS128 Antibody (Cat.#AP3582a) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.
Phospho-DCX-pS128 Antibody - Research Areas
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BACKGROUND
In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. It contains two doublecortin domains, which bind microtubules. In addition, this protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in the gene encoding DCX are a cause of X-linked lissencephaly.
REFERENCES
Leger,P.L., Neurogenetics (2008) Zhang,Y., Biochem. Biophys. Res. Commun. 363 (3), 694-700 (2007)
