|Application ||DB, E|
|Calculated MW||212007 Da|
|Other Names||Plexin-D1, PLXND1, KIAA0620|
|Target/Specificity||This PLXND1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1642 of human PLXND1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Phospho-PLXND1(Y1642) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity). Mediates anti-angiogenic signaling in response to SEMA3E.|
|Cellular Location||Cell membrane; Single-pass membrane protein|
|Tissue Location||Detected at low levels in heart, placenta, lung, skeletal muscle, kidney, thymus and liver. Detected at very low levels in brain, colon, spleen, small intestine and peripheral blood leukocytes.|
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Provided below are standard protocols that you may find useful for product applications.
This protein belongs to calcium-dependent cell adhesion molecule family.
van der Zwaag B.,Dev. Dyn. 225:336-343(2002).
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