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Phospho-IPF-pS66 AntibodyPeptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP3618a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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Phospho-IPF-pS66 Antibody - Product info | |
| Application | DB
|
| Primary Accession | P52945 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 30771 Da |
Phospho-IPF-pS66 Antibody - Additional info | |
| Gene ID 3651 | |
| Other Names PDX1; IPF1; Pancreas/duodenum homeobox protein 1; Glucose-sensitive factor; Insulin promoter factor 1; Insulin upstream factor 1; Islet/duodenum homeobox-1; Somatostatin-transactivating factor 1 | |
| Target/Specificity This Phospho-IPF-pS66 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between 50~80 amino acids surrounding S66 of human IPF. | |
| Dilution DB~~1:500 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by two-step phosphospecific peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Phospho-IPF-pS66 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
Phospho-IPF-pS66 Antibody - Protein Information | |
| Name PDX1 | |
| Synonyms IPF1, STF1 | |
| Function Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3' During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell | |
| Cellular Location Nucleus. Cytoplasm, cytosol (By similarity). | |
| Tissue Location Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells) | |
Phospho-IPF-pS66 Antibody - Related products
AP3617a: Phospho-IPF-pT11 Antibody
AP3618a: Phospho-IPF-pS66 Antibody
AP3669a: Phospho-PDX1-T11 Antibody
AP7740a: PDX1 Antibody (N-term)
AP7740b: IPF Antibody (C-term)
BP3617a: Phospho-IPF-pT11 Antibody Blocking Peptide
BP3618a: Phospho-IPF-pS66 Antibody Blocking Peptide
BP3669a: Phospho-PDX1-T11 Antibody Blocking Peptide
BP7740a: IPF Antibody (N-term) Blocking Peptide
BP7740b: IPF Antibody (C-term) Blocking Peptide
Phospho-IPF-pS66 Antibody - Application data
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Dot blot analysis of anti-Phospho-IPF-pS66 Antibody (Cat.#AP3618a) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.
Phospho-IPF-pS66 Antibody - Research Areas
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BACKGROUND
PDX1 is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
REFERENCES
Khoo S, et al. (2003) J Biol Chem 278, 32969-77
