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Phospho-PHB2-pY248 AntibodyPeptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP3622a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
Phospho-PHB2-pY248 Antibody - Product info | |
| Application | DB
|
| Primary Accession | Q99623 |
| Other Accession | NP_009204 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 33296 Da |
Phospho-PHB2-pY248 Antibody - Additional info | |
| Gene ID 11331 | |
| Other Names PHB2; BAP; REA; Prohibitin-2; B-cell receptor-associated protein BAP37; D-prohibitin; Repressor of estrogen receptor activity | |
| Target/Specificity This Phospho-PHB2-pY248 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between 233~262 amino acids surrounding Y248 of human PHB2. | |
| Dilution DB~~1:500 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by two-step phosphospecific peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Phospho-PHB2-pY248 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
Phospho-PHB2-pY248 Antibody - Protein Information | |
| Name PHB2 | |
| Synonyms BAP, REA | |
| Function Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging | |
| Cellular Location Mitochondrion inner membrane (By similarity). Cytoplasm (By similarity). Nucleus (By similarity) Note=Also cytoplasmic and nuclear (By similarity) | |
Phospho-PHB2-pY248 Antibody - Related products
AP3539a: Phospho-PHB2-Y128 Antibody
AP3622a: Phospho-PHB2-pY248 Antibody
AP7270a: REA (PHB2) Antibody (N-term)
AP7270b: REA (PHB2) Antibody (C-term)
BP3539a: Phospho-PHB2-Y128 Antibody Blocking Peptide
BP3622a: Phospho-PHB2-pY248 Antibody Blocking Peptide
BP7270a: PHB2 Antibody (N-term) Blocking Peptide
Phospho-PHB2-pY248 Antibody - Application data
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Dot blot analysis of anti-Phospho-PHB2-pY248 Antibody (Cat.#AP3622a) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.
Phospho-PHB2-pY248 Antibody - Research Areas
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BACKGROUND
PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. This protein functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. It competes with NCOA1 for modulation of ER transcriptional activity. It is probably involved in regulating mitochondrial respiration activity and in aging.
REFERENCES
Takata,H., Curr. Biol. 17 (15), 1356-1361 (2007) Kasashima,K., J. Biol. Chem. 281 (47), 36401-36410 (2006)
