|Application ||DB, E|
|Calculated MW||24549 Da|
|Other Names||Claudin-2, SP82, CLDN2|
|Target/Specificity||This CLDN2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y224 of human CLDN2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Phospho-CLDN2(Y224) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity.|
|Cellular Location||Cell junction, tight junction. Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Members of the claudin protein family, such as CLDN2, are expressed in an organ-specific manner and regulate the tissue-specific physiologic properties of tight junctions.
Morita,K., Proc. Natl. Acad. Sci. U.S.A. 96 (2), 511-516 (1999)
Furuse,M., J. Cell Biol. 141 (7), 1539-1550 (1998)
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