|Application ||DB, E|
|Calculated MW||24549 Da|
|Other Names||Claudin-2, SP82, CLDN2|
|Target/Specificity||This CLDN2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y224 of human CLDN2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Phospho-CLDN2(Y224) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity.|
|Cellular Location||Cell junction, tight junction. Cell membrane; Multi-pass membrane protein|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Members of the claudin protein family, such as CLDN2, are expressed in an organ-specific manner and regulate the tissue-specific physiologic properties of tight junctions.
Morita,K., Proc. Natl. Acad. Sci. U.S.A. 96 (2), 511-516 (1999)
Furuse,M., J. Cell Biol. 141 (7), 1539-1550 (1998)
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