- CITATIONS: 1
|Application ||IF, DB, E|
|Calculated MW||54671 Da|
|Other Names||Krueppel-like factor 4, Epithelial zinc finger protein EZF, Gut-enriched krueppel-like factor, KLF4, EZF, GKLF|
|Target/Specificity||This KLF4 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S254 of human KLF4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Phospho-KLF4(S254) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.|
Provided below are standard protocols that you may find useful for product applications.
Alder,J.K., J. Immunol. 180 (8), 5645-5652 (2008)
Natesampillai,S., Am. J. Physiol. Endocrinol. Metab. 294 (2), E385-E391 (2008)
Evans,P.M., J. Biol. Chem. 282 (47), 33994-34002 (2007)
Behr,R., Mol. Hum. Reprod. 13 (11), 815-820 (2007)
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