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Phospho-IGFBP-3-pS183 AntibodyPurified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP3684a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP3684a-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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- Backgrounds
Phospho-IGFBP-3-pS183 Antibody - Product info | |
| Application | DB
|
| Primary Accession | P17936 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 31674 Da |
Phospho-IGFBP-3-pS183 Antibody - Additional info | |
| Gene ID 3486 | |
| Other Names IGFBP3; IBP3; Insulin-like growth factor-binding protein 3 | |
| Target/Specificity This Phospho-IGFBP-3-pS183 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between 168~198 amino acids surrounding pS183 of human IGFBP-3. | |
| Dilution DB~~1:500 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by two-step phosphospecific peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Phospho-IGFBP-3-pS183 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
Phospho-IGFBP-3-pS183 Antibody - Protein Information | |
| Name IGFBP3 | |
| Synonyms IBP3 | |
| Function IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R | |
| Cellular Location Secreted. | |
| Tissue Location Expressed by most tissues. Present in plasma. | |
Phospho-IGFBP-3-pS183 Antibody - Related products
AP3684a: Phospho-IGFBP-3-pS183 Antibody
AP7641a: IGFBP3 Antibody (N-term)
AP7641b: IGFBP3 Antibody (C-term)
AP7641d: IGFBP3 Antibody (S183)
RI12662: IGFBP3 predesign siRNA
BP3684a: Phospho-IGFBP-3-pS183 Antibody Blocking Peptide
BP7641a: IGFBP3 Antibody (N-term) Blocking Peptide
Phospho-IGFBP-3-pS183 Antibody - Application data
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Dot blot analysis of anti-Phospho-IGFBP-3-pS183 Pab (Cat. #AP3684a) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.
Phospho-IGFBP-3-pS183 Antibody - Research Areas
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
IGFBP3 is a member of the insulin-like growth factor binding protein (IGFBP) family with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors.
REFERENCES
Muzumdar,R.H., Diabetes 55 (10), 2788-2796 (2006) Novosyadlyy,R., Growth Horm. IGF Res. 15 (5), 313-323 (2005)
