|Application ||IF, DB, E|
|Calculated MW||33520 Da|
|Other Names||Homeobox protein CDX-2, CDX-3, Caudal-type homeobox protein 2, CDX2, CDX3|
|Target/Specificity||This CDX2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S283 of human CDX2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Phospho-CDX2(S283) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (PubMed:28473536).|
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Provided below are standard protocols that you may find useful for product applications.
The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear proteins that bind to specific sequences within the promoter of the insulin gene (INS; MIM 176730) and interact with RNA polymerase to activate or repress transcription. The proteins LMX1 (MIM 600298) and CDX3 are homeodomain proteins that bind an A/T-rich sequence in the insulin promoter and stimulate its transcription.
Benoit, Y.D., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 298 (4), G504-G517 (2010)
Xie, Y., et al. Int. J. Oncol. 36(2):509-516(2010)
Park do, Y., et al. Mod. Pathol. 23(1):54-61(2010)
Lora, V., et al. Anticancer Res. 29(12):5033-5037(2009)
Porjazova, E., et al. Akush Ginekol (Sofiia) 48(4):32-34(2009)
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