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Phospho-PUM2- S182 AntibodyPeptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP3721a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP3721a-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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Phospho-PUM2- S182 Antibody - Product info | |
| Application | DB
|
| Primary Accession | Q8TB72 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 114216 Da |
Phospho-PUM2- S182 Antibody - Additional info | |
| Gene ID 23369 | |
| Other Names PUM2; KIAA0235; PUMH2; Pumilio homolog 2 | |
| Target/Specificity This Phospho-PUM2-S182 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between 167~196 amino acids surrounding S182 of human PUM2. | |
| Dilution DB~~1:500 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by two-step phosphospecific peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Phospho-PUM2- S182 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
Phospho-PUM2- S182 Antibody - Protein Information | |
| Name PUM2 | |
| Synonyms KIAA0235, PUMH2 | |
| Function Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts | |
| Cellular Location Cytoplasm (Probable). Cytoplasmic granule (By similarity). Cytoplasm, perinuclear region. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Co-localizes with NANOS3 in the stress granules (By similarity). Co-localizes with NANOS1 and SNAPIN in the perinuclear region of germ cells | |
| Tissue Location Expressed in male germ cells of adult testis (at protein level). Highly expressed in testis and ovary Predominantly expressed in stem cells and germ cells. Expressed at lower level in brain, heart, kidney, liver, muscle, placenta, intestine and stomach Expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata and putamen Expressed in all fetal tissues tested | |
Phospho-PUM2- S182 Antibody - Related products
AP3721a: Phospho-PUM2- S182 Antibody
AP3733a: Phospho-PUM2- S136 Antibody
AP7569b: PUM2 Antibody (N-term)
BP3721a: Phospho-PUM2-S182 Antibody Blocking Peptide
BP3733a: Phospho-PUM2-S136 Antibody Blocking peptide
BP5827a: PUM2-S136 Antibody Blocking peptide
Phospho-PUM2- S182 Antibody - Application data
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Dot blot analysis of anti-Phospho-PUM2-S182 Phospho-specific Pab (Cat. #AP3721a ) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.
Phospho-PUM2- S182 Antibody - Research Areas
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BACKGROUND
PUM2 is sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. It is interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts.
REFERENCES
Ginter-Matuszewska, B., et al. Mol. Hum. Reprod. 15(3):173-179(2009) Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007) Kusz, K., et al. Mol. Reprod. Dev. 74(6):795-799(2007)
