|Application ||DB, E|
|Other Accession||P48432, NP_003097.1, P54231|
|Calculated MW||34310 Da|
|Other Names||Transcription factor SOX-2, SOX2|
|Target/Specificity||This Sox2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S249 of human Sox2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Phospho-Sox2(S249) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
Tung, C.L., et al. Biochem. Biophys. Res. Commun. 393(3):420-425(2010)
Laga, A.C., et al. Am. J. Pathol. 176(2):903-913(2010)
Gu, H.F., et al. Gend Med 6(4):555-564(2009)
Schneider, A., et al. Am. J. Med. Genet. A 149A (12), 2706-2715 (2009) :
Zhang, X., et al. Mol. Vis. 15, 2911-2918 (2009) :
Gure, A.O., et al. Proc. Natl. Acad. Sci. U.S.A. 97(8):4198-4203(2000)
Kamachi, Y., et al. Trends Genet. 16(4):182-187(2000)
Helland, R., et al. Acta Crystallogr. D Biol. Crystallogr. 55 (PT 1), 139-148 (1999) :
Yuan, H., et al. Genes Dev. 9(21):2635-2645(1995)
Stevanovic, M., et al. Mamm. Genome 5(10):640-642(1994)
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