Register or Login
Catalog #
  • All
  • Uniprot Id
  • Catalog #
>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   APG3(cleaved) Antibody   

APG3(cleaved) Antibody

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • DB - APG3(cleaved) Antibody AP3740a
    Dot blot analysis of anti-APG3-cleaved Pab (Cat. #AP3740a) on nitrocellulose membrane. 50ng of Cleaved-peptide or Non Cleaved-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.
  • SPECIFICATION
  • CITATIONS: 0
  • PROTOCOLS
  • BACKGROUND
Product Information
ApplicationDB, E
Primary AccessionQ9NT62
Other AccessionQ6AZ50, Q9CPX6, Q6PFS7, Q0VCL3
ReactivityHuman
PredictedBovine, Zebrafish, Mouse, Rat
HostRabbit
ClonalityPolyclonal
IsotypeRabbit Ig
Calculated MW35864 Da
Antigen Region90-104 aa
Additional Information
Gene ID64422
Other NamesUbiquitin-like-conjugating enzyme ATG3, 632-, Autophagy-related protein 3, APG3-like, hApg3, Protein PC3-96, ATG3, APG3, APG3L
Target/SpecificityThis APG3-cleaved Antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide 90-104aa selected from human APG3.
DilutionDB~~1:500
FormatPurified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Protein Information
NameATG3
SynonymsAPG3, APG3L
Function E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12- ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
Cellular Location Cytoplasm.
Tissue LocationWidely expressed, with a highest expression in heart, skeletal muscle, kidney, liver and placenta
Research Areas
Citations (0)

Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.

Submit your citation using an Abgent antibody to
info@abgent.com, and receive a free "I Love Antibodies" mug.
FeedBack
Abgent welcomes feedback from its customers.

If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.

If you have any additional inquiries please email technical services at tech@abgent.com.

$ 265.00
$ 95.00
Cat# AP3740a
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
Request Quote Here

Ordering Information

United States
AlbaniaAustraliaAustriaBelgiumBosnia & HerzegovinaBrazilBulgariaCanadaChinaCroatiaCyprusCzech RepublicDenmarkEstoniaFinlandFranceGermanyGreeceHong KongHungaryIcelandIndiaIndonesiaIrelandIsraelItalyJapanKoreaLatviaLithuaniaLuxembourgMacedoniaMalaysiaMaltaNetherlandsNew ZealandNorwayPakistanPolandPortugalRomaniaSerbiaSingaporeSlovakiaSloveniaSouth AfricaSpainSwedenSwitzerlandTaiwanTurkeyUnited KingdomUnited StatesVietnamOthers
Abgent, Inc.
(888) 735-7227 / (858) 622-0099
(858) 622-0609 / (858) 430-3418

Shipping Information

Domestic orders (in stock items)
Shipped out the same day. Orders placed after 1 PM (PST) will ship out the next business day.
International orders
Contact your local distributors
Crown Flash 13 July
Customer Service
Terms & Conditions