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APG3(cleaved) Antibody

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Country
United States
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Ordering Information
Catalog # Size Availability Price  
AP3740a 400 µl In Stock $ 265.00 Add to cart
AP3740a-ev 80 µl In Stock $ 95.00 Add to cart
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APG3(cleaved) Antibody - Product info

ApplicationDB
  • Applications Legend:
  • WB=Western Blotting
  • IP=Immunoprecipitation
  • IHC-P=Immunohistochemistry (Paraffin)
  • IF-IC=Immunofluorescence (Immunocytochemistry)
  • FC=Flow Cytometry
  • DB=Dot Blot
Primary AccessionQ9NT62
Other AccessionQ6AZ50, Q9CPX6, Q6PFS7, Q0VCL3
ReactivityHuman
PredictedMouse, Rat, Zebrafish, Bovine
IsotypeRabbit Ig
Calculated MW35864 Da

APG3(cleaved) Antibody - Additional info

Gene ID 64422
Other Names
ATG3; APG3; APG3L; Ubiquitin-like-conjugating enzyme ATG3; Autophagy-related protein 3; Protein PC3-96
Target/Specificity
This APG3-cleaved Antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide 90-104aa selected from human APG3.
Dilution
DB~~1:500
Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions
APG3(cleaved) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

APG3(cleaved) Antibody - Protein Information

Name ATG3
Synonyms APG3, APG3L
Function
E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12- ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
Cellular Location
Cytoplasm.
Tissue Location
Widely expressed, with a highest expression in heart, skeletal muscle, kidney, liver and placenta

APG3(cleaved) Antibody - Related products

AP1807a: ATG3 Antibody (N-term)

AP1807b: ATG3 Antibody (C-term)

AP1807c: ATG3 Antibody (C-term K183)

BP1807a: APG3L Antibody (N-term) Blocking Peptide

BP1807b: APG3L Antibody (C-term) Blocking Peptide

BP3740a: APG3 - cleaved Antibody blocking peptides

APG3(cleaved) Antibody - Research Areas

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