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Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
United StatesOrdering Information
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|AP3740a||400 µl||In Stock||$ 265.00||DISCONTINUED INQUIRE CLICK INQUIRE Add to cart|
|AP3740a-ev||80 µl||In Stock||$ 95.00||DISCONTINED INQUIRE CLICK INQUIRE Add to cart|
- Citations : 0
APG3(cleaved) Antibody - Product Information
|Other Accession||Q6AZ50, Q9CPX6, Q6PFS7, Q0VCL3|
|Predicted||Bovine, Zebrafish, Mouse, Rat|
|Calculated MW||35864 Da Da|
|Antigen Region||90-104 aa|
APG3(cleaved) Antibody - Additional Information
|Gene ID 64422|
Ubiquitin-like-conjugating enzyme ATG3, 632-, Autophagy-related protein 3, APG3-like, hApg3, Protein PC3-96, ATG3, APG3, APG3L
This APG3-cleaved Antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide 90-104aa selected from human APG3.
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
APG3(cleaved) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
APG3(cleaved) Antibody - Protein Information
|Synonyms APG3, APG3L|
E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12- ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
Widely expressed, with a highest expression in heart, skeletal muscle, kidney, liver and placenta
APG3(cleaved) Antibody - Related Products
APG3(cleaved) Antibody - Research Areas
Dot blot analysis of anti-APG3-cleaved Pab (Cat. #AP3740a) on nitrocellulose membrane. 50ng of Cleaved-peptide or Non Cleaved-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.
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