|Application ||IF, DB, E|
|Other Accession||P48432, NP_003097.1, P54231|
|Calculated MW||34310 Da|
|Other Names||Transcription factor SOX-2, SOX2|
|Target/Specificity||This Sox2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S246 of human Sox2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||phospho-Sox2(S246) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
References for protein:
1.Gen, Y., et al. Cancer Genet. Cytogenet. 202(2):82-93(2010)
2.Ji, J., et al. Hum. Pathol. 41(10):1438-1447(2010)
3.Fang, X., et al. OMICS 14(4):369-384(2010)
4.Sholl, L.M., et al. Am. J. Surg. Pathol. 34(8):1193-1198(2010)
5.Zhang, D., et al. BMC Med. Genet. 11, 116 (2010)
References for SY5Y (SH-SY5Y; ATCC#CRL-2266): 1. Ross RA, et al. Coordinate morphological and biochemical interconversion of human neuroblastoma cells. J. Natl. Cancer Inst. 71: 741-749, 1983. [PubMed: 6137586]; 2. Biedler JL, et al. Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones. Cancer Res. 38: 3751-3757, 1978. [PubMed: 29704].
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