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Belcin 1 phosphoPeptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP3765a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP3765a-ev20 | Ev20 size 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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- Backgrounds
Belcin 1 phospho - Product info | |
| Application | DB
|
| Primary Accession | Q14457 |
| Other Accession | Q6GP52, Q91XJ1, Q4A1L5, O88597, Q5ZKS6, Q4A1L4, NP_003757.1 |
| Reactivity | Human |
| Predicted | Bovine, Chicken, Mouse, Pig, Rat, Xenopus |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 51896 Da |
Belcin 1 phospho - Additional info | |
| Gene ID 8678 | |
| Other Names BECN1; GT197; Beclin-1; Coiled-coil myosin-like BCL2-interacting protein; Protein GT197 | |
| Target/Specificity This Beclin 1 phospho antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide around T119 of Beclin 1. | |
| Dilution DB~~1:100~500 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by two-step phosphospecific peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Belcin 1 phospho is for research use only and not for use in diagnostic or therapeutic procedures. | |
Belcin 1 phospho - Protein Information | |
| Name BECN1 | |
| Synonyms GT197 | |
| Function Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | |
| Cellular Location Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note=Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity) | |
| Tissue Location Ubiquitous. | |
Belcin 1 phospho - Related products
AM1818a: Beclin 1 Antibody (Ascites)
AM1818b: BECN1 Antibody (Ascites)
AP14089a: BECN1 Antibody (N-term T72)
AP1818c: Beclin 1 Antibody (C-term)
AP8653a: Beclin1-BH3 Domain Antibody
RI10583: BECN1 predesign siRNA
LY10584a: BECN1 Over-expression Lysate
BP1818a: BECN1 Antibody (Q196) Blocking Peptide
BP1818b: BECN1 Antibody (E225) Blocking Peptide
BP1818c: BECN1 Antibody (C-term) Blocking Peptide
Belcin 1 phospho - Application data
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Dot blot analysis of Beclin 1 phospho antibody Phospho-specific Pab (Cat. #AP3765a) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.
Belcin 1 phospho - Research Areas
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BACKGROUND
Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009 [PubMed 19270693]).[supplied by OMIM].
REFERENCES
Koukourakis, M.I., et al. Br. J. Cancer 103(8):1209-1214(2010) Jaeger, P.A., et al. Arch. Neurol. 67(10):1181-1184(2010) Metzger, S., et al. Hum. Genet. 128(4):453-459(2010) Oberstein, A., et al. J. Biol. Chem. 282(17):13123-13132(2007) Furuya, N., et al. Autophagy 1(1):46-52(2005)
