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Phospho-rat PARP1(S373) Antibody

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • DB - Phospho-rat PARP1(S373) Antibody AP3786i
    Dot blot analysis of Phospho-rat PARP1-S373 Antibody Phospho-specific Pab (Cat. #AP3786i) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
DB, E
Primary Accession P27008
Other Accession NP_037195.1
Reactivity Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 112660 Da
Additional Information
Gene ID 25591
Other Names Poly [ADP-ribose] polymerase 1, PARP-1, ADP-ribosyltransferase diphtheria toxin-like 1, ARTD1, NAD(+) ADP-ribosyltransferase 1, ADPRT 1, Poly[ADP-ribose] synthase 1, Parp1, Adprt
Target/Specificity This rat PARP1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S373 of rat PARP1.
Dilution DB~~1:500
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPhospho-rat PARP1(S373) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Parp1
Synonyms Adprt
Function Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Mediates the poly(ADP-ribosyl)ation of histones in a HPF1-dependent manner. Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00264}. Nucleus, nucleolus Note=Localizes at sites of DNA damage.
Research Areas
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Background

catalyzes poly (ADP-ribose) protein modification; plays a role in DNA repair and genome stability [RGD].

References

Beneke, S., et al. Mech. Ageing Dev. 131(5):366-369(2010)
Kondo, K., et al. J. Biol. Chem. 285(17):13079-13091(2010)
Zaalishvili, G., et al. Biochem. Biophys. Res. Commun. 393(1):123-125(2010)
Drel, V.R., et al. Endocrinology 150(12):5273-5283(2009)
Adamczyk, A., et al. Folia Neuropathol 47(3):247-251(2009)

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$ 295.00
$ 99.00
Cat# AP3786i
Size:
Quantity:
(40 western blots)
Availability: In Stock
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