|Application ||DB, E|
|Calculated MW||133958 Da|
|Other Names||Tight junction protein ZO-2, Tight junction protein 2, Zona occludens protein 2, Zonula occludens protein 2, TJP2, X104, ZO2|
|Target/Specificity||This TJP2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S978 of human TJP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Phospho-TJP2(S978) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in tight junctions and adherens junctions.|
|Cellular Location||Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, tight junction. Nucleus. Note=Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures.|
|Tissue Location||This protein is found in epithelial cell junctions. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutation in this gene have been identified in patients with hypercholanemia. Alternate splicing results in multiple transcript variants.
Lechuga, S., et al. Exp. Cell Res. 316(19):3124-3139(2010)
Remue, E., et al. FEBS Lett. 584(19):4175-4180(2010)
Walsh, T., et al. Am. J. Hum. Genet. 87(1):101-109(2010)
Meerschaert, K., et al. Cell. Mol. Life Sci. 66(24):3951-3966(2009)
Fanning, A.S., et al. Ann. N. Y. Acad. Sci. 1165, 113-120 (2009) :
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