Phospho-mouse TSC1(S321) Antibody
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| DB, E |
---|---|
Primary Accession | Q9EP53 |
Other Accession | NP_075025.2 |
Reactivity | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit Ig |
Calculated MW | 128746 Da |
Gene ID | 64930 |
---|---|
Other Names | Hamartin, Tuberous sclerosis 1 protein homolog, Tsc1, Kiaa0243 |
Target/Specificity | This mouse TSC1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S321 of mouse TSC1. |
Dilution | DB~~1:500 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Phospho-mouse TSC1(S321) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Tsc1 |
---|---|
Synonyms | Kiaa0243 |
Function | In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). |
Cellular Location | Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes. |

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Provided below are standard protocols that you may find useful for product applications.
Background
In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity).
References
Kladney, R.D., et al. Cancer Res. 70(21):8937-8947(2010)
Sathaliyawala, T., et al. Immunity 33(4):597-606(2010)
Scott, C.L., et al. Am. J. Physiol. Lung Cell Mol. Physiol. 299 (4), L455-L471 (2010) :
Bartolome, A., et al. Endocrinology 151(7):3084-3094(2010)
Squarize, C.H., et al. PLoS ONE 5 (5), E10643 (2010) :

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