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Phospho-CCNB2(S22) Antibody

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • DB - Phospho-CCNB2(S22) Antibody AP3838a
    Dot blot analysis of CCNB2 Antibody (Phospho S22) Phospho-specific Pab (Cat. #AP3838a) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
DB, E
Primary Accession O95067
Other Accession NP_004692.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 45282 Da
Additional Information
Gene ID 9133
Other Names G2/mitotic-specific cyclin-B2, CCNB2
Target/Specificity This CCNB2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S22 of human CCNB2.
Dilution DB~~1:500
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPhospho-CCNB2(S22) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCNB2
Function Essential for the control of the cell cycle at the G2/M (mitosis) transition.
Research Areas
Citations (0)
citation

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Background

Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control.

References

Cunningham, J.M., et al. Br. J. Cancer 101(8):1461-1468(2009)
Haraguchi, T., et al. Fertil. Steril. 91 (4 SUPPL), 1424-1426 (2009) :
De Martino, I., et al. Cancer Res. 69(5):1844-1850(2009)
Bellanger, S., et al. Oncogene 26(51):7175-7184(2007)
Stav, D., et al. Int. J. Biol. Markers 22(2):108-113(2007)

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$ 182.50
$ 70.00
Cat# AP3838a
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