|Application ||DB, E|
|Calculated MW||45282 Da|
|Other Names||G2/mitotic-specific cyclin-B2, CCNB2|
|Target/Specificity||This CCNB2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S22 of human CCNB2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Phospho-CCNB2(S22) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Essential for the control of the cell cycle at the G2/M (mitosis) transition.|
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Provided below are standard protocols that you may find useful for product applications.
Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control.
Cunningham, J.M., et al. Br. J. Cancer 101(8):1461-1468(2009)
Haraguchi, T., et al. Fertil. Steril. 91 (4 SUPPL), 1424-1426 (2009) :
De Martino, I., et al. Cancer Res. 69(5):1844-1850(2009)
Bellanger, S., et al. Oncogene 26(51):7175-7184(2007)
Stav, D., et al. Int. J. Biol. Markers 22(2):108-113(2007)
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