|Application ||WB, IHC-P, E|
|Calculated MW||119749 Da|
|Antigen Region||636-663 aa|
|Other Names||Protein transport protein Sec24A, SEC24-related protein A, SEC24A|
|Target/Specificity||This SC24A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 636-663 amino acids from the Central region of human SC24A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SC24A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.|
|Cellular Location||Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum membrane. Golgi apparatus membrane|
|Tissue Location||Expressed in fibroblasts, hepatocytes, and lymphocytes|
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Provided below are standard protocols that you may find useful for product applications.
SC24A is a component of coat protein II (COPII; see MIM 601924)-coated vesicles that mediate protein transport from the endoplasmic reticulum. SEC24A is 1 of several mammalian proteins that show structural and functional homology to yeast Sec24.
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Mancias, J.D., et al. Mol. Cell 26(3):403-414(2007)
Wendeler, M.W., et al. EMBO Rep. 8(3):258-264(2007)
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