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A2ML1 Antibody (N-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP4723a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP4723a-ev20 | Ev20 size 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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A2ML1 Antibody (N-term) - Product info | |
| Application | WB, FC
|
| Primary Accession | A8K2U0 |
| Reactivity | Human, Mouse |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 161107 Da |
A2ML1 Antibody (N-term) - Additional info | |
| Other Names A2ML1; CPAMD9; Alpha-2-macroglobulin-like protein 1; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9 | |
| Target/Specificity This A2ML1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 352~381 amino acids from the N-terminal region of human A2ML1. | |
| Dilution WB~~1:100~500WB~~1:1000 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions A2ML1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
A2ML1 Antibody (N-term) - Protein Information | |
| Name A2ML1 | |
| Synonyms CPAMD9 | |
| Function Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity) Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases | |
| Cellular Location Secreted. | |
| Tissue Location In the epidermis, expressed predominantly in the granular layer at the apical edge of keratinocytes (at protein level). Also detected in placenta, testis and thymus but not in epithelia of kidney, lung, small intestine or colon | |
A2ML1 Antibody (N-term) - Related products
A2ML1 Antibody (N-term) - Application data
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Western blot analysis of A2ML1 Antibody (N-term) (Cat. #AP4723a) in mouse lung tissue lysates (35ug/lane). A2ML1 (arrow) was detected using the purified Pab.
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A2ML1 Antibody (N-term) (Cat. #AP4723a) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
A2ML1 Antibody (N-term) - Research Areas
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
A2ML1 is a new member of the alpha 2-macroglobulin protease inhibitor family, and shares most the characteristics of this family. It is the first family member detected in the epidermis and may play an important role during desquamation by inhibiting extracellular proteases.
