SAC2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9Y2H2 |
Other Accession | Q8CDA1 |
Reactivity | Human |
Predicted | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 128407 Da |
Antigen Region | 133-161 aa |
Gene ID | 22876 |
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Other Names | Phosphatidylinositide phosphatase SAC2, 313-, Inositol polyphosphate 5-phosphatase F, Sac domain-containing inositol phosphatase 2, Sac domain-containing phosphoinositide 5-phosphatase 2, hSAC2, INPP5F, KIAA0966, SAC2 |
Target/Specificity | This SAC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-161 amino acids from the N-terminal region of human SAC2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SAC2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | INPP5F (HGNC:17054) |
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Synonyms | KIAA0966, SAC2 |
Function | Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity). |
Cellular Location | Membrane, clathrin-coated pit. Early endosome. Recycling endosome. Note=Also found on macropinosomes {ECO:0000250|UniProtKB:Q8CDA1} |
Tissue Location | Ubiquitous (PubMed:11274189). Highly expressed in brain (PubMed:26203138). |
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Provided below are standard protocols that you may find useful for product applications.
Background
SAC2 is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants have been observed, but most of them are not thought to be protein-coding.
References
Zhu, W., et al. Circ. Res. 105(12):1240-1247(2009)
Thole, J.M., et al. Plant Cell 20(2):381-395(2008)
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
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