|Application ||WB, IHC-P, FC, E|
|Calculated MW||49460 Da|
|Antigen Region||394-423 aa|
|Other Names||GPI mannosyltransferase 1, 241-, GPI mannosyltransferase I, GPI-MT-I, Phosphatidylinositol-glycan biosynthesis class M protein, PIG-M, PIGM|
|Target/Specificity||This PIGM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 394-423 amino acids from the C-terminal region of human PIGM.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PIGM Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
PIGM encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI)-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. PIGM encodes a mannosyltransferase, GPI-MT-I, that transfers the first mannose to GPI on the lumenal side of the endoplasmic reticulum.
Almeida, A.M., et al. Nat. Med. 12(7):846-851(2006) Maeda, Y., et al. EMBO J. 20 (1-2), 250-261 (2001) Kinoshita, T., et al. Curr Opin Chem Biol 4(6):632-638(2000)
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