|Application ||WB, FC, E|
|Calculated MW||134609 Da|
|Antigen Region||767-795 aa|
|Other Names||CST complex subunit CTC1, Conserved telomere maintenance component 1, HBV DNAPTP1-transactivated protein B, CTC1, C17orf68|
|Target/Specificity||This CQ068 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 767-795 amino acids from the Central region of human CQ068.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CQ068 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.|
|Cellular Location||Nucleus. Chromosome, telomere. Note=A transmembrane region is predicted by sequence analysis tools (ESKW, MEMSAT and Phobius); however, given the telomeric localization of the protein, the relevance of the transmembrane region is unsure in vivo|
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Provided below are standard protocols that you may find useful for product applications.
CQ068 is subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication. CQ068 also appears to function in a telomere-associated complex with OBFC1 and TEN1.
Surovtseva, Y.V., et al. Mol. Cell 36(2):207-218(2009)
Miyake, Y., et al. Mol. Cell 36(2):193-206(2009)
Casteel, D.E., et al. J. Biol. Chem. 284(9):5807-5818(2009)
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