|Application ||WB, E|
|Calculated MW||118325 Da|
|Antigen Region||443-470 aa|
|Other Names||Protein transport protein Sec24C, SEC24-related protein C, SEC24C, KIAA0079|
|Target/Specificity||This SEC24C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 443-470 amino acids from the Central region of human SEC24C.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SEC24C Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.|
|Cellular Location||Cytoplasm. Cytoplasm, perinuclear region Endoplasmic reticulum membrane. Golgi apparatus membrane|
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Provided below are standard protocols that you may find useful for product applications.
SEC24C is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The product of this gene may play a role in shaping the vesicle, as well as in cargo selection and concentration.
Stagg, S.M., et al. Cell 134(3):474-484(2008)
Yamayoshi, S., et al. Cell Host Microbe 3(3):168-177(2008)
Morgan, A.R., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B (6), 762-770 (2007)
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