|Application ||WB, IHC-P, FC, E|
|Other Accession||Q8C6A8, Q71T09|
|Calculated MW||36997 Da|
|Antigen Region||236-264 aa|
|Other Names||Class E basic helix-loop-helix protein 22, bHLHe22, Class B basic helix-loop-helix protein 5, bHLHb5, Trinucleotide repeat-containing gene 20 protein, BHLHE22, BHLHB5, TNRC20|
|Target/Specificity||This BHLHB5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-264 amino acids from the Central region of human BHLHB5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BHLHB5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity).|
|Tissue Location||Brain-specific, with the highest expression in the cerebellum.|
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Provided below are standard protocols that you may find useful for product applications.
BHLHB5 inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. BHLHB5 despite the presence of an intact basic domain, does not bind to DNA.
Stevens, J.D., et al. Differentiation 76(9):1006-1022(2008)
McLellan, A.S., et al. Mech. Dev. 119 SUPPL 1, S285-S291 (2002)
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