- Antibodies
- New
- Biological Process >
- Cellular Compartment >
- Disease >
- Molecular Function >
- Pathway Biocarta >
- Pathway KEGG >
- Pathway Panther >
- Tissue >
- Tag
- Peptides
- Biological Process >
- Cellular Compartment >
- Disease >
- Molecular Function >
- Pathway Biocarta >
- Pathway KEGG >
- Pathway Panther >
- Tissue >
- Amino Acids
- Tag
- Biological Process >
- Proteins
- RNAi
- FL cDNA Clones
- Cell/Tissues/Lysates
ABCC11 Antibody (N-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
Australia Austria Belgium Brazil Bulgaria Canada China Croatia Cyprus Czech Republic Denmark Estonia Finland France Germany Greece Hungary Iceland India Indonesia Ireland Israel Italy Japan Korea Latvia Lithuania Luxembourg Macedonia Malaysia Malta Netherlands Norway Pakistan Poland Portugal Romania Serbia Singapore Slovakia Slovenia Spain Sweden Switzerland Taiwan Turkey United Kingdom United States Vietnam Others 
|
|||
|---|---|---|---|---|
| Catalog # | Size | Availability | Price | |
| AP4787a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP4787a-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
ABCC11 Antibody (N-term) - Product info | |
| Application | WB, IHC
|
| Primary Accession | Q96J66 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 154301 Da |
ABCC11 Antibody (N-term) - Additional info | |
| Gene ID 85320 | |
| Other Names ABCC11; MRP8; ATP-binding cassette sub-family C member 11; Multidrug resistance-associated protein 8 | |
| Target/Specificity This ABCC11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 350~380 amino acids from the N-terminal region of human ABCC11. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:50~100 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ABCC11 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ABCC11 Antibody (N-term) - Protein Information | |
| Name ABCC11 | |
| Synonyms MRP8 | |
| Function Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Probably functions to secrete earwax | |
| Cellular Location Membrane; Multi-pass membrane protein. | |
| Tissue Location Expressed in many tissues. Not expressed in kidney, spleen and colon. Highly expressed in breast cancer Expressed at moderate levels in normal breast and testis and at very low levels in liver, brain and placenta | |
ABCC11 Antibody (N-term) - Related products
AP4787a: ABCC11 Antibody (N-term)
ABCC11 Antibody (N-term) - Application data
-
Western blot analysis of ABCC11 Antibody (N-term) (Cat. #AP4787a) in WiDr cell line lysates (35ug/lane). ABCC11 (arrow) was detected using the purified Pab.
-
ABCC11 Antibody (N-term) (Cat. #AP4787a) IHC analysis in formalin fixed and paraffin embedded breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ABCC11 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
ABCC11 Antibody (N-term) - Research Areas
Abgent welcomes feedback from its customers.
If you have used an Abgent product and would like to share how it has performed, please click on the
"Submit Review" button and provide the requested information. Our staff will examine and post your
review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abgent.com.
Thank you for your support.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
ABCC11 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1.
REFERENCES
Martin, A., et al. J. Invest. Dermatol. 130(2):529-540(2010) J. Hum. Genet. 54(9):499-503(2009) Sato, T., et al. J. Hum. Genet. 54(7):409-413(2009)
