- CITATIONS: 1
|Application ||WB, IHC-P, FC, E|
|Calculated MW||38453 Da|
|Antigen Region||212-241 aa|
|Other Names||Acetylserotonin O-methyltransferase, Hydroxyindole O-methyltransferase, HIOMT, ASMT|
|Target/Specificity||This ASMT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 212-241 amino acids from the Central region of human ASMT.|
|Precautions||ASMT Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5- methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity.|
|Tissue Location||Expressed in the pineal gland (at protein level). In the retina, very low expression is found at the mRNA level (PubMed:7989373), and not at the protein level (PubMed:8574683).|
Provided below are standard protocols that you may find useful for product applications.
ASMT belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland.
Melke, J., et al. Mol. Psychiatry 13(1):90-98(2008)
Toma, C., et al. Mol. Psychiatry 12(11):977-979(2007)
Ross, M.T., et al. Nature 434(7031):325-337(2005)
Itoh, M.T., et al. Horm. Metab. Res. 35(3):153-157(2003)
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