|Application ||WB, IHC-P, FC, E|
|Calculated MW||91747 Da|
|Antigen Region||786-812 aa|
|Other Names||Telomere length regulation protein TEL2 homolog, Protein clk-2 homolog, hCLK2, TELO2, KIAA0683|
|Target/Specificity||This TELO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 786-812 amino acids from the C-terminal region of human TELO2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TELO2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation.|
|Cellular Location||Cytoplasm. Membrane. Nucleus. Chromosome, telomere|
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Provided below are standard protocols that you may find useful for product applications.
TELO2 is a protein that functions as an S-phase checkpoint protein in the cell cycle. The protein may also play a role in DNA repair.
Collis, S.J., et al. Mol. Cell 32(3):313-324(2008)
Takai, H., et al. Cell 131(7):1248-1259(2007)
Collis, S.J., et al. Nat. Cell Biol. 9(4):391-401(2007)
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