TOX3 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application
| FC, WB, IHC-P, E |
---|---|
Primary Accession | O15405 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 63342 Da |
Antigen Region | 214-242 aa |
Gene ID | 27324 |
---|---|
Other Names | TOX high mobility group box family member 3, CAG trinucleotide repeat-containing gene F9 protein, Trinucleotide repeat-containing gene 9 protein, TOX3, CAGF9, TNRC9 |
Target/Specificity | This TOX3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 214-242 amino acids from the Central region of human TOX3. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | TOX3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TOX3 |
---|---|
Synonyms | CAGF9, TNRC9 |
Function | Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen- responsive C3 promoter region. |
Cellular Location | Nucleus. |
Tissue Location | Expressed mainly in epithelial cells. Expressed in the central nervous system (CNS), in the ileum and within the brain in the frontal and occipital lobe. |
Provided below are standard protocols that you may find useful for product applications.
Background
TOX3 contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer.
References
Wacholder, S., et al. N. Engl. J. Med. 362(11):986-993(2010)
Odefrey, F., et al. Cancer Res. 70(4):1449-1458(2010)
Couch, F.J., et al. Cancer Epidemiol. Biomarkers Prev. 18(11):3044-3048(2009)
Stacey, S.N., et al. Nat. Genet. 39(7):865-869(2007)
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