SETD6 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q8TBK2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 53189 Da |
Antigen Region | 310-338 aa |
Gene ID | 79918 |
---|---|
Other Names | N-lysine methyltransferase SETD6, 211-, SET domain-containing protein 6, SETD6 |
Target/Specificity | This SETD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 310-338 amino acids from the C-terminal region of human SETD6. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SETD6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SETD6 {ECO:0000303|PubMed:21515635, ECO:0000312|HGNC:HGNC:26116} |
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Function | Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulation of NF-kappa-B transcription factor activity (PubMed:21131967, PubMed:30189201, PubMed:21515635). Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (PubMed:23324626). Required for the maintenance of embryonic stem cell self-renewal (By similarity). Methylates PAK4. |
Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
References
Kimura, K., et al. Genome Res. 16(1):55-65(2006)
Gerhard, D.S., et al. Genome Res. 14 (10B), 2121-2127 (2004)
Suzuki, Y., et al. Genome Res. 14(9):1711-1718(2004)
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