|Application ||WB, IHC-P, E|
|Calculated MW||53189 Da|
|Antigen Region||310-338 aa|
|Other Names||N-lysine methyltransferase SETD6, 211-, SET domain-containing protein 6, SETD6|
|Target/Specificity||This SETD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 310-338 amino acids from the C-terminal region of human SETD6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SETD6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protein-lysine N-methyltransferase. Monomethylates 'Lys- 310' of the RELA subunit of NF-kappa-B complex, leading to down- regulate NF-kappa-B transcription factor activity (PubMed:21131967). Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (PubMed:23324626). Required for the maintenance of embryonic stem cell self-renewal (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
Kimura, K., et al. Genome Res. 16(1):55-65(2006)
Gerhard, D.S., et al. Genome Res. 14 (10B), 2121-2127 (2004)
Suzuki, Y., et al. Genome Res. 14(9):1711-1718(2004)
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