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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   C19orf21 Antibody (N-term)   

C19orf21 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - C19orf21 Antibody (N-term) AP4851a
    Western blot analysis of C19orf21 Antibody (N-term) (Cat. #AP4851a) in HepG2 cell line lysates (35ug/lane). C19orf21 (arrow) was detected using the purified Pab.
  • IHC-P - C19orf21 Antibody (N-term) AP4851a
    C19orf21 Antibody (N-term) (Cat. #AP4851a) IHC analysis in formalin fixed and paraffin embedded human cervix carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the C19orf21 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - C19orf21 Antibody (N-term) AP4851a
    C19orf21 Antibody (N-term) (Cat. #AP4851a) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8IVT2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 75357 Da
Antigen Region 63-91 aa
Additional Information
Gene ID 126353
Other Names Mitotic interactor and substrate of PLK1, Mitotic spindle positioning protein, MISP, C19orf21
Target/Specificity This C19orf21 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-91 amino acids from the N-terminal region of human C19orf21.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsC19orf21 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms C19orf21
Function Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus.
Cellular Location Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Predominantly localizes to cortical actin structures during interphase and mitosis Present in retraction fibers, which are formed at former adhesion sites during mitosis, and at spicular membrane protrusions in re- attaching cytokinetic cells. Partially colocalizes with cytoplasmic F-actin. Not detected at microtubules at interphase, nor at spindle during mitosis
Research Areas
Citations (0)

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The exact function of C19orf21 remains unknown.


Olsen, J.V., et al. Cell 127(3):635-648(2006)
Nousiainen, M., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5391-5396(2006)
Kim, J.E., et al. J. Proteome Res. 4(4):1339-1346(2005)

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$ 295.00
$ 99.00
Cat# AP4851a
(40 western blots)
Availability: In Stock
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