|Application ||WB, FC, E|
|Other Accession||Q00195, Q28718, Q62398, Q03041|
|Predicted||Bovine, Mouse, Rabbit, Rat|
|Calculated MW||76048 Da|
|Antigen Region||75-102 aa|
|Other Names||Cyclic nucleotide-gated olfactory channel, Cyclic nucleotide-gated cation channel 2, Cyclic nucleotide-gated channel alpha-2, CNG channel alpha-2, CNG-2, CNG2, CNGA2, CNCA, CNCA1, CNCG2|
|Target/Specificity||This CNGA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-102 amino acids from the N-terminal region of human CNGA2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CNGA2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CNCA, CNCA1, CNCG2|
|Function||Odorant signal transduction is probably mediated by a G- protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
CNGA2 represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation.
Qu, W., et al. J. Gen. Physiol. 127(4):375-389(2006)
Hofmann, F., et al. Pharmacol. Rev. 57(4):455-462(2005)
Yoo, D., et al. J. Biol. Chem. 279(8):6863-6873(2004)
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