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CCR1 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CCR1 Antibody (N-term) AP4859a
    Western blot analysis of CCR1 Antibody (N-term) (Cat. #AP4859a) in 293 cell line lysates (35ug/lane). CCR1 (arrow) was detected using the purified Pab.
  • IHC-P - CCR1 Antibody (N-term) AP4859a
    CCR1 Antibody (N-term) (Cat. #AP4859a) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CCR1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - CCR1 Antibody (N-term) AP4859a
    CCR1 Antibody (N-term) (Cat. #AP4859a) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P32246
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 41173 Da
Antigen Region 1-30 aa
Additional Information
Gene ID 1230
Other Names C-C chemokine receptor type 1, C-C CKR-1, CC-CKR-1, CCR-1, CCR1, HM145, LD78 receptor, Macrophage inflammatory protein 1-alpha receptor, MIP-1alpha-R, RANTES-R, CD191, CCR1, CMKBR1, CMKR1, SCYAR1
Target/Specificity This CCR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CCR1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCCR1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCR1
Synonyms CMKBR1, CMKR1, SCYAR1
Function Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Widely expressed in different hematopoietic cells
Research Areas
Citations (0)

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CCR1 encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p.


Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)
Anderson, M.W., et al. Am. J. Clin. Pathol. 133(3):473-483(2010)
Amundsen, S.S., et al. Genes Immun. 11(1):79-86(2010)

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Cat# AP4859a
(40 western blots)
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