|Application ||WB, FC, E|
|Calculated MW||29233 Da|
|Antigen Region||193-219 aa|
|Other Names||Cyclic AMP-dependent transcription factor ATF-1, cAMP-dependent transcription factor ATF-1, Activating transcription factor 1, Protein TREB36, ATF1|
|Target/Specificity||This ATF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 193-219 amino acids from the C-terminal region of human ATF1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ATF1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.|
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Provided below are standard protocols that you may find useful for product applications.
ATF1 binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. ATF1 binds to the Tax-responsive element (TRE) of HTLV-I. ATF1 mediates PKA-induced stimulation of CRE-reporter genes.
Wang, W.L., et al. Mod. Pathol. 22(9):1201-1209(2009)
Vega, A., et al. Gynecol. Oncol. 112(1):210-214(2009)
Zheng, D., et al. Cancer Res. 68(18):7650-7660(2008)
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