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CST3 Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP4872b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP4872b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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- Citiations : 0
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CST3 Antibody (C-term) - Product info | |
| Application | WB, IHC, FC
|
| Primary Accession | P01034 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 15799 Da |
CST3 Antibody (C-term) - Additional info | |
| Gene ID 1471 | |
| Other Names CST3; Cystatin-C; Cystatin-3; Gamma-trace; Neuroendocrine basic polypeptide; Post-gamma-globulin | |
| Target/Specificity This CST3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between amino acids 100-130 from the C-terminal region of human CST3. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:50~100 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions CST3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
CST3 Antibody (C-term) - Protein Information | |
| Name CST3 | |
| Function As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity | |
| Cellular Location Secreted. | |
| Tissue Location Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in various body fluids, such as the cerebrospinal fluid and plasma Expressed in highest levels in the epididymis, vas deferens, brain, thymus, and ovary and the lowest in the submandibular gland | |
CST3 Antibody (C-term) - Related products
AP4872b: CST3 Antibody (C-term)
LY10271a: CST3 Over-expression Lysate
CST3 Antibody (C-term) - Application data
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Western blot analysis of CST3 Antibody (C-term) (Cat. #AP4872b) in NCI-H460 cell line lysates (35ug/lane). CST5 (arrow) was detected using the purified Pab.
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CST3 Antibody (C-term) (Cat. #AP4872b) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CST3 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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CST3 Antibody (C-term) (Cat. #AP4872b) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
CST3 Antibody (C-term) - Research Areas
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BACKGROUND
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body.
REFERENCES
Maetzler, W., et al. J. Alzheimers Dis. 19(3):937-942(2010) Choe, J.Y., et al. J. Korean Med. Sci. 25(1):42-48(2010) Ge, C., et al. Clin Cardiol 32(11):644-648(2009)
