|Application ||WB, FC, E|
|Calculated MW||27574 Da|
|Antigen Region||98-124 aa|
|Other Names||Tetraspanin-7, Tspan-7, Cell surface glycoprotein A15, Membrane component chromosome X surface marker 1, T-cell acute lymphoblastic leukemia-associated antigen 1, TALLA-1, Transmembrane 4 superfamily member 2, CD231, TSPAN7, A15, DXS1692E, MXS1, TM4SF2|
|Target/Specificity||This TSPAN7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-124 amino acids from the Central region of human TSPAN7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TSPAN7 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||A15, DXS1692E, MXS1, TM4SF2|
|Function||May be involved in cell proliferation and cell motility.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Not solely expressed in T-cells. Expressed in acute myelocytic leukemia cells of some patients|
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Provided below are standard protocols that you may find useful for product applications.
TSPAN7 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. This gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy.
Radhakrishnan, Y., et al. Biol. Reprod. 81(4):647-656(2009)
Guilmatre, A., et al. Arch. Gen. Psychiatry 66(9):947-956(2009)
Noor, A., et al. Psychiatr. Genet. 19(3):154-155(2009)
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