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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   YMEL1 Antibody (N-term)   

YMEL1 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - YMEL1 Antibody (N-term) AP4882a
    Western blot analysis of YMEL1 Antibody (N-term) (Cat. #AP4882a) in HepG2 cell line lysates (35ug/lane). YMEL1 (arrow) was detected using the purified Pab.
  • WB - YMEL1 Antibody (N-term) AP4882a
    Western blot analysis of YMEL1 Antibody (N-term) (Cat. #AP4882a) in CHO cell line lysates (35ug/lane). YMEL1 (arrow) was detected using the purified Pab.
  • IHC-P - YMEL1 Antibody (N-term) AP4882a
    YMEL1 Antibody (N-term) (Cat. #AP4882a) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the YMEL1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - YMEL1 Antibody (N-term) AP4882a
    YMEL1 Antibody (N-term) (Cat. #AP4882a) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, FC, E
Primary Accession Q96TA2
Other Accession Q925S8, O88967
Reactivity Human, Hamster
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 86455 Da
Antigen Region 191-219 aa
Additional Information
Gene ID 10730
Other Names ATP-dependent zinc metalloprotease YME1L1, 3424-, ATP-dependent metalloprotease FtsH1, Meg-4, Presenilin-associated metalloprotease, PAMP, YME1-like protein 1, YME1L1, FTSH1, YME1L
Target/Specificity This YMEL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 191-219 amino acids from the N-terminal region of human YMEL1.
Dilution WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsYMEL1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name YME1L1
Synonyms FTSH1, YME1L
Function Putative ATP-dependent protease. Plays a role in mitochondrial organization and mitochondrial protein metabolism, including degradation of PRELID1 and OPA1 (PubMed:18076378, PubMed:27495975). Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1).
Cellular Location Mitochondrion inner membrane Mitochondrion
Tissue Location High expression in cardiac and skeletal muscle mitochondria.
Research Areas
Citations (0)

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Background

YMEL1 is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies.

References

Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
Deloukas, P., et al. Nature 429(6990):375-381(2004)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)

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Cat# AP4882a
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(40 western blots)
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