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GSDMA Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - GSDMA Antibody (N-term) AP4887a
    Western blot analysis of GSDMA Antibody (N-term) (Cat. #AP4887a) in mouse liver tissue lysates (35ug/lane). GSDMA (arrow) was detected using the purified Pab.
  • IHC-P - GSDMA Antibody (N-term) AP4887a
    GSDMA Antibody (N-term) (Cat. #AP4887a) IHC analysis in formalin fixed and paraffin embedded human skin carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the GSDMA Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - GSDMA Antibody (N-term) AP4887a
    GSDMA Antibody (N-term) (Cat. #AP4887a) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, FC, E
Primary Accession Q96QA5
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 49365 Da
Antigen Region 66-94 aa
Additional Information
Gene ID 284110
Other Names Gasdermin-A, Gasdermin-1, GSDMA, GSDM, GSDM1
Target/Specificity This GSDMA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the N-terminal region of human GSDMA.
Dilution WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGSDMA Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GSDMA
Synonyms GSDM, GSDM1
Function May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity (PubMed:27281216). The physiological relevance of these observations is unknown (Probable).
Cellular Location Cytoplasm, perinuclear region. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P57764}. Cell membrane {ECO:0000250|UniProtKB:P57764}
Tissue Location Expressed predominantly in the gastrointestinal tract and, at a lower level, in the skin. Also detected in mammary gland. In the gastrointestinal tract, mainly expressed in differentiated cells, including the differentiated cell layer of esophagus and mucus-secreting pit cells of the gastric epithelium. Down-regulateded in gastric cancer cells
Research Areas
Citations (0)

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Background

GSDMA induces apoptosis.

References

Soranzo, N., et al. Nat. Genet. 41(11):1182-1190(2009)
Saeki, N., et al. Genes Chromosomes Cancer 48(3):261-271(2009)
Tamura, M., et al. Genomics 89(5):618-629(2007)

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$ 295.00
$ 99.00
Cat# AP4887a
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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