|Application ||WB, FC, E|
|Calculated MW||32783 Da|
|Antigen Region||113-141 aa|
|Other Names||Ermin, Juxtanodin, JN, ERMN, KIAA1189|
|Target/Specificity||This ERMIN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 113-141 amino acids from the Central region of human ERMIN.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ERMIN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton.|
|Tissue Location||Highly expressed in adult and fetal brain. Expressed at intermediate levels in the lung and liver|
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Provided below are standard protocols that you may find useful for product applications.
ERMIN plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. ERMIN may play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS.
Brockschnieder, D., et al. J. Neurosci. 26(3):757-762(2006)
Zhang, B., et al. Proc. Natl. Acad. Sci. U.S.A. 102(32):11527-11532(2005)
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