|Application ||WB, IHC-P, FC, E|
|Other Accession||Q4FZT6, Q8BFU2, Q7L7L0, P0CC09, Q6GSS7, Q6FI13, P02262, P22752, P0C0S9, P0C170, P20671, P0C169, Q93077, P04908|
|Predicted||Rat, Bovine, Mouse|
|Calculated MW||14091 Da|
|Antigen Region||103-130 aa|
|Other Names||Histone H2A type 1, H2A1, Histone H2A/p, HIST1H2AG, H2AFP|
|Target/Specificity||This HIST1H2AL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-130 amino acids from the C-terminal region of human HIST1H2AL.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HIST1H2AL Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|
|Cellular Location||Nucleus. Chromosome.|
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Provided below are standard protocols that you may find useful for product applications.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.
Lusic, M., et al. EMBO J. 22(24):6550-6561(2003)
Kzhyshkowska, J., et al. Biochem. J. 371 (PT 2), 385-393 (2003)
Marzluff, W.F., et al. Genomics 80(5):487-498(2002)
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