|Application ||WB, IHC-P, FC, E|
|Calculated MW||97502 Da|
|Antigen Region||841-870 aa|
|Other Names||MICAL-like protein 2, Junctional Rab13-binding protein, Molecule interacting with CasL-like 2, MICAL-L2, MICALL2, JRAB|
|Target/Specificity||This MILK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 841-870 amino acids from the C-terminal region of human MILK2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Precautions||MILK2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity).|
|Cellular Location||Cell membrane; Peripheral membrane protein. Cell junction, tight junction. Recycling endosome. Cell projection. Cytoplasm, cytoskeleton. Cytoplasm, cytosol|
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Provided below are standard protocols that you may find useful for product applications.
MILK2 may be a cytoskeletal regulator.
Kanda, I., et al. Oncogene 27(12):1687-1695(2008)
Terai, T., et al. Mol. Biol. Cell 17(5):2465-2475(2006)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Terman, J.R., et al. Cell 109(7):887-900(2002)
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