|Application ||WB, IHC-P, E|
|Calculated MW||63747 Da|
|Antigen Region||458-487 aa|
|Other Names||Tumor necrosis factor receptor superfamily member 8, CD30L receptor, Ki-1 antigen, Lymphocyte activation antigen CD30, CD30, TNFRSF8, CD30, D1S166E|
|Target/Specificity||This TNFRSF8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 458-487 amino acids from human TNFRSF8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TNFRSF8-Y479 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF- kappa-B.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
TNFRSF8 is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity.
Braun, F.K., et al. J. Invest. Dermatol. 130(3):826-840(2010)
Azarpira, N., et al. Saudi J Kidney Dis Transpl 21(1):31-36(2010)
Edinger, J.T., et al. Am. J. Surg. Pathol. 33(12):1860-1868(2009)
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